Further, NF-kB/IL-6 induces the expression of DNA (cytosine-5)-methyltransferase 1 (DNMT1), which downregulates the suppressor of cytokine signaling 3 (SOCS 3) needed for the regulation of cytokine-induced STAT3 signaling, leading to CRC oncogenesis [172]. This evidence concerns the gene STAT3 and colorectal carcinoma.