Based on the identified TFEB-associated genes, we established a prognostic CRC signature with a combination of eight genes (PLSCR3, SERPINA1, ATP6V1C2, TIMP1, SORT1, MAP2, KDM4B, and DDAH2) and an equation for calculating a TRS (Figure 4). The gene discussed is PLSCR3; the disease is colorectal carcinoma.