NSAID administration in vitro was reported to enhance TNF-α-mediated and TRAIL-induced cell death in different cancer cells through various mechanisms [162,163,164,165,166,167], of which aspirin and ibuprofen may be the least potent, while celecoxib and tamoxifen may be the most potent anti-inflammatory and anti-proliferative agents [168]. Here, TNF is linked to cancer.