In addition, oxycodone combined with flurbiprofen axetil applied for IVPCA could effectively reduce pain intensity, reverse immunosuppression, inhibit the release of serum TNF-α, and enhance postoperative intestinal recovery compared with sufentanil combined with flurbiprofen axetil in patients undergoing radical resections of colorectal cancer [151]. This evidence concerns the gene TNF and colorectal cancer.