TNF and colonic neoplasm: In addition, Geng et al. reported that, compared with allogeneic suspended RBC transfusion, allogeneic leukocyte-depleted RBC transfusion could effectively alleviate inflammation with a less decreased level of serum TNF-α, improve coagulation function, reduce stress response, and enhance wound healing without increasing adverse reactions or the postoperative infection rate in patients with recurrences of colon cancer after operation [221].