GNAQ and uveal melanoma: However, another study has found that AMOT, rather than Lats1/2, serves as the bridge between GPCR-mediated cytoskeleton changes and YAP/TAZ modulation in uveal melanoma cells, with an activated mutation at Arg183 and Gly209 in GNAQ (encoding for Gαq) and GNA11 (encoding for Gα11), respectively [85].