The large and ever-grossing body of sequencing by pan-cancer analysis suggests that the frequently mutated GPCR families are adhesion-related GPCRs, such as the glutamate metabotropic receptors (GRM1-8, class C) [59], lysophosphatidic acid (LPA) receptors (LPAR1-6), sphingosine-1-phosphate (S1P) receptors (S1PR1-5), and muscarinic receptors (CHRM1-5, class A). Here, LGR6 is linked to cancer.