Although GNAQ and GNA11 mutations were less studied in tumors than GNAS, these mutations were well-established in Sturge-Weber syndrome [79] and leptomeningeal melanocytosis, arising from the central nervous system (~50%) [80], and also in the blue nevi and the primary uveal melanomas (UVM)/uveal melanoma metastases (83%) [81,82]. This evidence concerns the gene GNA11 and uveal melanoma.