ACTA1 and neoplasm: By utilizing organoid co-culture models of PDAC tumor cells and PSCs, Öhlund et al. identified CAFs characterized by αSMA-positivity (named myofibroblastic CAFs: myCAFs) as well as another subpopulation characterized by the secretion of inflammatory mediators such as IL6 and a lack of αSMA expression (named inflammatory CAFs: iCAFs) [162].