AKT1 and breast cancer: Adiponectin also has anti-proliferative and anti-metastatic functions in BC, which are exerted via the following relevant mechanisms: adiponectin binds to adiponectin receptors AdipoR1 and AdipoR2 to inhibit BC cell growth and migration by activating AMP-activated protein kinase (AMPK) and inhibiting the PI3K/AKT/mammalian target of rapamycin (mTOR) and c-Src (proto-oncogene)/mitogen-activated protein kinase (MAPK) signaling pathways [45].