Type I IFN was elevated when adipocytes were co-cultured with BC cells which led to recruitment of the HIF-1α–IFN-γ-inducible protein 16 (IFI16)–protein arginine N-methyltransferase 2 (PMT2) complex to activate the PI.3/PII promoter in adipocytes and upregulate the expression of aromatase to promote the growth of ER+ BC [107,108]. This evidence concerns the gene ESR1 and breast cancer.