MiR-378 has also been shown to be overexpressed and associated with an increased risk of BM and “brain-seeking” metastatic potential, due to its role in promoting cell migration, invasion, and tumor angiogenesis through modulation of MMP-2, MMP-9, VEGF, and suppressor-of-fused (SUFU) genes [96]. Here, VEGFA is linked to neoplasm.