ONECUT2 and cancer: A number of novel biomarkers (such as ADXBLADDER, CxBladder Triage and Xpert) or combinations (FGFR3 + TERT + HRAS + OXT1 + ONECUT2 + TWIST) were also reported to have high negative predictive values, indicating potential utility in community settings, as reassurance can be provided that cancer is an unlikely outcome [28,29].