AR and Familial prostate cancer: In our study of the antiandrogenic activity of WBM in prostate cancer, 5 prostate cancer cell lines (LNCaP, VCaP, PC-3, DU-145, and 22RV1) that have captured histological (prostate adenocarcinoma) and molecular features (AR-positive, AR-negative, AR-variants) of human prostate cancers are selected and 1 prostate normal epithelial cell line (RWPE1) have been used as in vitro models [181,184].