PEITC suppressed the proliferation and induced apoptosis in SW480 colon cancer cells and attenuated mRNA expression of proinflammatory cytokines such as interleukin 8 (IL8), CCL2, and CXCL10 and mediated down-regulation of MMP7, STAT1, and NF-κB. The gene discussed is CXCL8; the disease is malignant colon neoplasm.