PEITC also down-regulated PcG complex proteins, including B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), enhancer of zeste homolog 2 (EZH2), and suppressor of zeste 12 homolog (SUZ12), whereas long-term PEITC exposure to colon cancer cells caused the hypomethylation of PcG target genes such as Protocadherin 10 (PCDH10), von Willebrand factor C domain containing 2 (VWC2), Spastic Paraplegia 20 (SPG20), Hepatocyte Nuclear Factor 4 (HNF4A), and cadherin 6 (CDH6) [59]. This evidence concerns the gene VWC2 and colonic neoplasm.