Pancreatic cancer cells transfected with miR-375 showed the down-regulation of insulin-like growth factor-binding protein-5 (IGFBP5) and caveolin-1 (CAV1), and BITC possibly targeted the up-regulation of IGFBP5 and CAV-1 through suppressing the expression of miR-221 and miR-375 [79]. The gene discussed is IGFBP5; the disease is familial pancreatic carcinoma.