BITC treatment resulted in a significant up-regulation of miR-99a-5p, which further down-regulated insulin-like growth factor 1 receptor (IGFR1), mammalian target of rapamycin (mTOR), and fibroblast growth factor receptor 3 (FGFR3), leading to decreased cell viability and apoptosis induction in bladder cancer cells through the cleavage of poly (ADP-ribose) polymerase (cPARP) and pro-caspase-3 [77]. Here, FGFR3 is linked to urinary bladder carcinoma.