SFRP1 and familial pancreatic carcinoma: Furthermore, we found that the mean methylation change from pancreatic normal to tumor tissue of the CGI2 CpGs (0.22 to 0.29) is significantly higher than the mean methylation change of the 5’CpGs upstream of CGI2 (13 CpGs with 0.04 to 0.22) and the 3’CpGs downstream of CGI2 (15 CpGs with −0.08 to 0.19), pointing out the crucial role of CGI2 in SFRP1 promoter methylation in pancreatic cancer (Figure 2B) (overview of all TCGA CpG sites in Supplementary Table S3).