GSK3B and familial pancreatic carcinoma: One cellular signaling pathway that seems to be involved in pancreatic cancer development and maintenance of cancer stem cells is the canonical Wnt pathway [12,13], which regulates nuclear β-catenin concentration by degradation via the so-called destruction complex built from adenomatosis polyposis coli (APC), glycogen synthase kinase 3 beta (GSK-3β) and axin proteins.