IL6 and cancer: Moreover, the combination of IL-6 and TNFR2+ Tregs achieved an excellent predictive ability (AUC 1.000) (Figure 5) in identifying patients with malignant tumors, and this was superior to AUC values for CA125 and HE4 (AUC value ranges 0.986–0.997) (Table 3 and Table 4).