Hamilton et al. looking at the molecular mechanism of the induction of TNFR2 in colon cancer cell lines, reported that TNFR2 induction, although it requires TNF in combination with IL-6 to enhance expression of TNFR2, may be induced sufficiently by IL-6-mediated STAT3 activation alone [82]. Here, TNFRSF1B is linked to malignant colon neoplasm.