Three genes were concordantly decreased in EGFR-amplified versus non-amplified tumours: COL11A1, UBASH3B (ubiquitin associated and SH3 domain containing B, known to inhibit endocytosis of the EGF–EGFR complex [20]), and PPT2 (palmitoyl-protein thioesterase 2), visualised on volcano plots in Figure 3a,b. The gene discussed is EGFR; the disease is neoplasm.