Moreover, given that LG cancer is relatively indolent, and some authors consider it eligible for active surveillance [10,11], important concerns arise, whether incidental diagnosis might in fact have been responsible for the unnecessary detection of tumors with small malignant potentials, similar to prostate-specific antigen screening having led to an overdiagnosis of low-risk prostate cancer cases [12]. Here, KLK3 is linked to prostate carcinoma.