In the spontaneous T-ALL model that we reported previously [40], loss of IL-15 or IL-15Rα in NOD mice with severe combined immunodeficiency (NOD.Scid) resulted in T-ALL development in all mice by 8 months of age, indicating a crucial role for IL-15 signaling in preventing leukemogenesis. This evidence concerns the gene IL15 and acute lymphoblastic leukemia.