Han et al. prepared a nanomicelles system TPP-PEG-PCL loaded with norcantharidin, which significantly increased the uptake of the natural drug molecule nortriptyline by tumor cells and aggregated the drug in mitochondria, enhancing antitumor efficacy by decreasing mitochondrial membrane potential, increasing intracellular ROS levels, decreasing Bax, and increasing Bcl-2 expression [120]. Here, BCL2 is linked to neoplasm.