Gamma delta T cells (γδ T cells), which account for around 5–10% of the T-cell population, are one of the most promising candidates for off-the-shelf CAR production, as γδ TCR expressed on the surface of γδ T cell is MHC-independent, thereby reducing the risk of GVHD [72]. The gene discussed is HLA-C; the disease is graft versus host disease.