MSLN and malignant pleural mesothelioma: In this study, 27 patients with malignant pleural disease (either as primary or pleural metastases) received intrapleural mesothelin targeting CAR-T; 25 of these patients had a diagnosis of malignant pleural mesothelioma (MPM), and 18 of them received pembrolizumab after CAR-T cell therapy.