FABP5 and neoplasm: Further, we summarize the emerging role of epidermal fatty acid binding protein (E-FABP, or FABP5), a previously underappreciated lipid sensor in T cells, in modulating fatty acid metabolism and responses in different T cell subsets [14,15,16], which highlights a new concept of how the modulation of lipid metabolism by FABP5 influences the anti-tumor function of T cells in the TME.