In detail, high levels of immune inhibitory cells in the TME such as tumor-infiltrating lymphocytes (TILs) and Tregs may favor the expression of transforming growth factor-β (TGF-β) or increase the levels of CTLA4 and PD-L1, suppressing the immune response in patients affected by HCC [21,22]. Here, CD274 is linked to hepatocellular carcinoma.