CAR was functional and specific because the CAR-TILs (but not mock-transfected TILs) from patient MM1 degranulated, released, and caused accumulation of interferon gamma (IFN-γ) in the medium when co-cultured with the HER2 positive uveal melanoma cell line 92-1 (Figure 1b–d). The gene discussed is ERBB2; the disease is uveal melanoma.