HP and cancer: For example, the increased expression of nipped-B-like protein is significantly linked with poor prognosis, tumor differentiation, and lymph node metastasis in non-small cell lung cancer [20], Beta ig-h3 plays a role in mesothelioma tumorigenesis and progression [21], periostin, haptoglobin, protein AMBP fragments are upregulated in various cancers including MPM [22,23,24], whereas galectin-3 binding protein are associated to prognosis and progression of various cancers [25].