The most common LOH present in 21 cases, including both follicular thyroid adenoma (10 cases) and follicular thyroid carcinoma (11 cases), was 16p12.1 comprising over 7.5 Mbp in size, encompassing 149 known genes, including many important cancer-related genes such as TP53 and its variants, UBE2MP1, ATP2A1, IL27, TGFB, MAPK3, BCL7C, and many transcription factor subunit genes. Here, MAPK3 is linked to thyroid gland follicular carcinoma.