SAT1 and cancer: Catabolism of polyamines is mediated by spermidine/spermine N1-acetyltranferase (SSAT), which is responsive to intracellular polyamine pools, resulting in the formation of acetylated polyamine derivatives, such as diacetylspermine (DAS), that can be secreted into the surrounding microenvironment and can be detected in peripheral blood, providing potential utility for cancer detection [22].