EPHA3 was downregulated in BLCA (p = 1.3 × 104), colon adenocarcinoma (COAD, p = 1.2 × 104), uterine corpus endometrial carcinoma (UCEC, p = 2.1 × 103), kidney chromophobe (KICH, p = 2.4 × 107), prostate carcinoma (PRAD, p = 0.03), thyroid carcinoma (THCA, p = 1.6 × 1010), and rectal adenocarcinoma (READ, p = 3.9 × 103) when they were compared with the normal tissues. This evidence concerns the gene EPHA3 and colon adenocarcinoma.