While intra-tumoral IgG4 has demonstrated an association with increased IL-4 and IL-10 production and decreased ADCC and antibody-dependent cellular phagocytosis of tumor cells in melanoma, higher levels of IgG4 had positive prognostic associations in lung squamous cell carcinoma and sub-types of lung adenocarcinoma [102,103,104]. This evidence concerns the gene IL10 and neoplasm.