POSTN interacts with cell-surface receptor integrins such as αvβ3, αvβ5, and α6β4 to modulate intracellular signaling pathways in cancer cells and accelerate cell adhesion, survival, invasion, angiogenesis, metastasis, and epithelial–mesenchymal transition (EMT) [8,10,12]. The gene discussed is POSTN; the disease is cancer.