Furthermore, in vitro co-culture experiments identified the upregulation of basal STAT3 and tyrosine 705 (Y705)-phosphorylated STAT3 in fibroblasts co-cultured with CRC cells (Figure 6), indicating activation of the canonical IL-6/JAK/STAT3 pathway due to the CRC cells. The gene discussed is STAT3; the disease is colorectal carcinoma.