ANGPT2 and neoplasm: Thus, we also speculated that if other tumor angiogenic factors increase, including angiopoietin-2 (ANG-2), fibroblast growth factor (FGF), hepatocyte growth factor (HGF), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF)-C, and VEGF-D, it might cause resistance to VEGF-A inhibitors and the combination treatment of ICIs and VEGF-A inhibitors.