In order to study the role of IDH in low-grade glioma in vivo, Sasaki et al. generated Nes-Idh1R132H/wt (Nes-KI) mice and control Nes-Idh1wt/wt (Nes-WT) mice using Cre Lox technology with the Nestin promoter as the driver for expression of mutant IDH [43]. Here, NES is linked to central nervous system cancer.