TLR4 and glioblastoma: The effect of LPS and MET treatment, used alone and in combination, on U87MG and A172 GBM cell lines, was analyzed given that both present TLR4 expression [37] (Supplementary Figure S1A), and the fact that an increased apoptotic rate with the use of LPS and TMZ co-treatment in U87MG cells has been previously demonstrated by our group [24].