HIF1A and neoplasm: The results demonstrate that the NIR PS produces 1O2 under near-infrared irradiation, which enables the disassembly and lysosomal escape of siRNA and ASO, and inhibits the hypoxia-inducible factor-1 (HIF-1) and B-cell lymphoma 2 (Bcl-2) expressions, eventually inhibiting tumor growth [77].