The role of miR-221/222 in the modulation of KIT and the PI3K/AKT pathway in GIST was confirmed by Ihle et al. who demonstrated that transient transfection of miR-221/222 reduced GIST cell viability and induced apoptosis by inhibition of KIT expression and its downstream signalling cascade [29]. Here, AKT1 is linked to gastrointestinal stromal tumor.