PAX3 and alveolar rhabdomyosarcoma: While no formal etiology has yet been defined, multiple gene rearrangements have been associated with an increased risk of certain soft tissue sarcoma subtypes, such as in Ewing’s sarcoma (EWSR1–FLI-1 fusion), myxoid liposarcoma (TLS–CHOP fusion), alveolar rhabdomyosarcoma (PAX3–FHKR fusion) and synovial sarcoma (SSX–SYT fusion) [5].