We demonstrated that knocking down FASN expression in HCT116-LOHP and HCT8-LOHP cells using lentiviral vectors inhibited the accumulation of triglycerides and lipid droplets (Figure 2A) and lowered the IC50 of oxaliplatin in the CRC cell lines (HCT8-LOHP-NC 22.34 μmol/L vs. HCT8-LOHP-shFASN 8.69 μmol/L, p = 0.024; HCT116-LOHP-NC 22.24 μmol/L vs. HCT116-LOHP-shFASN 13.7 μmol/L, p = 0.013) (Figure 2B). This evidence concerns the gene FASN and colorectal carcinoma.