Therefore, we suspect that miR-148/152 family may have low expression in gastric cancer, while overexpression of miR-148/152 family members could target and inhibit the ITGA5 gene, thereby inhibiting the self-renewal ability, clonal formation ability and drug resistance of gastric cancer stem cells, and ultimately preventing the phenotypic formation of gastric cancer stem cells. The gene discussed is ITGA5; the disease is gastric cancer.