On the other hand, pathway analysis indicated that the onsets of IDC and SLE both were correlated with the changes of multiple components in the IFN-JAK-STAT signaling pathway, including STAT1, OAS1, OASL, and PML (Additional file 5: Figure S2, Additional file 1: Table S4, and Table S5). Here, PML is linked to systemic lupus erythematosus.