On the other hand, pathway analysis indicated that the onsets of IDC and SLE both were correlated with the changes of multiple components in the IFN-JAK-STAT signaling pathway, including STAT1, OAS1, OASL, and PML (Additional file 5: Figure S2, Additional file 1: Table S4, and Table S5). This evidence concerns the gene STAT1 and systemic lupus erythematosus.