The current vision of AD suggests two main directions in the disease pathophysiology: 1) disorders in the epidermal barrier as a result of a genetically determined absence or violation of the filaggrin synthesis — a protein involved in the construction of the stratum corneum and components of the natural moisturizing factor [6]; 2) immunological disorders with a predominance of the Th2-immune response with the key cytokines IL-1, IL-4, IL-5, IL-13, IL-31 but the list of candidate cytokines and immune mediators of inflammation is constantly expanding. Here, FLG is linked to Alzheimer disease.