CpG 685 downregulated miR-21, further upregulated PTEN, and ultimately reversed the drug resistance of imatinib caused by BCR-ABL1-independent AKT phosphorylation at Ser473 in Ph+ B-ALL cells (Fig. 4D, F, Additional file 1: Figure S4B). This evidence concerns the gene AKT1 and acute lymphoblastic leukemia.