NLRP3 and deafness: The R260W (also known as R262W) variation of NLRP3 gene was first reported in 2002 and its involvement in MWS and FCU was confirmed, but some clinical symptoms, such as deafness, AA-type amyloidosis, and cold sensitivity, do not always exist, indicating that NLRP3 gene variation is not an independent pathogenic factor, and there may be epigenetic and other factors involved in the pathogenesis.