In 2012, the expert group developed a set of practice guidelines for hereditary recurrent fever (HRF), which pointed out some specific gene variation sites of CAPS (p.R260W, p.D303N, p.L305P, p.E311K, p.T348M, p.L353P, p.A439V, p.V198M, and p.Q703K) [21]. The gene discussed is CAPS; the disease is Fever.