The IL-8-251 (rs4073) “T” allele was found to increase risk of MSA in a dose-dependent manner despite having lower transcriptional activity than the “A” allele, a relationship that strengthened in individuals who also carry the intercellular adhesion molecule-1 (ICAM-1: E469K) “KK” genotype [167]. The gene discussed is ICAM1; the disease is multiple system atrophy.