The heatmap demonstrated that the infiltration of HL tumor (High ligand tumor) is higher in Cluster B compared with Cluster A, and there is notable difference between these two cluster in Macrophage Proliferating, Classical Monocyte, CD4 + HSPA1A + T cell, TAM3 MT1G + , TAM1 SPP1 + , Non-classical Monocyte, HL_Tumor and dendritic cells. This evidence concerns the gene SPP1 and neoplasm.