we identified numerous CD4 + (expressing IL7R), and CD8 + T cell populations (expressing CD8A), natural killer (NK) populations (expressing GNLY, NKG7), small populations of B cells (expressing MS4A1/CD20) and population of myeloid (LYZ, CD14, S100A8, S100A9), Among non-immune clusters, we identified tumor cells (expressing CA9) and normal kidney epithelial cells (expressing ALDOB), and fibroblast (expressing ACTA2, THY1). The gene discussed is S100A9; the disease is neoplasm.