Consistent with previous studies [18, 20, 21], PIL mice exhibited several representative lupus-like manifestations, including lipogranuloma, elevated serum cytokines, chemokines and autoantibodies, immune complex-mediated nephritis with renal failure and proteinuria, arthritis, as well as splenomegaly (Fig. 2). The gene discussed is SERPINA2; the disease is systemic lupus erythematosus.