CD274 and gastric cancer: Although the clinical significance of CPS and the best cut-off point for ICI treatment have not been determined due to the rapid clinical development of ICIs and based on limited data, these observations support ICIs as another treatment option for GC/GEJC in PD-L1 CPS ≥ 1 individuals [67] according to the immunohistochemistry of PD-L1 [68].