In the present study, regarding the importance of memory (CD45RO +) and cytotoxic (CD8 +) lymphocytes in eradication of tumor cells, we attempted to delineate the presence of CD3 + , CD8 + , CD45RO + TILs and the expression of LAG3, as a novel inhibitory marker, in both IM and CT of CRC tissues and then assessed their correlation with clinical outcomes with the focus on tumor location. The gene discussed is CD8A; the disease is neoplasm.