However, no significant relationships were observed between the mean frequency of CD3 + and CD8 + cells and clinicopathological features, as shown in Table 3, the mean frequency of CD45RO + lymphocytes in CT, was higher in patients with lymph node metastasis (P = 0.016) and those with advanced TNM-stages (III/IV) (P = 0.037) comparing to node-negative and lower-staged patients (I/II), respectively. This evidence concerns the gene CD8A and metastatic malignant neoplasm in the lymph nodes.