In addition, the early release of cytochrome C may be related to hematoma occupation, ischemia and hypoxia of peripheral neurons caused by brain edema, energy metabolism disorder, calcium overload, oxidative stress and the production of a large number of free radicals.The mechanism by which DTT can block the release of cytochrome C is related to the mitochondrial permeability transition pore channel and the Bcl-2 family of proteins. This evidence concerns the gene BCL2 and brain edema.