To further explore the impact of a pyroptosis gene (NLRC4) on sepsis at a deeper level, we predicted the upstream targeting factor miRNAs and lncRNAs and constructed a ceRNA network of 6 lncRNAs (MIR29B2CHG, TMEM161B-AS1, KCNQ1OT1, NEAT1, AC016876.2, XIST) and 2 miRNAs (hsa-miR-335-5p, hsa-miR-146a-5p) around NLRC4. This evidence concerns the gene XIST and Sepsis.