In the current study, conducted in a group of patients with high cardiovascular risk undergoing major non-cardiac surgery, we have analysed the frequency of myocardial injury (MINS) detected with high-sensitive troponin T (hs-cTnT), the occurrence of subclinical coronary artery disease (CAD) detected with advanced imaging techniques, and the occurrence of cardiovascular complications after one year follow-up. Here, TNNT2 is linked to coronary artery disorder.