Bivariate analysis revealed a significant association between ENE + and c/pDOI > 10 mm and between ENE + and MMP14 expression in the tumour nest (high) and CAFs (positive); the analysis was based on the co-scoring system (high risk) in biopsies and resected specimens (all p < 0.05, Table 5). The gene discussed is MMP14; the disease is neoplasm.