We explored XRCC4 expression in tumor and normal tissues from the TIMER database and found that XRCC4 was significantly upregulated in 11 cancer types, including, bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), head and neck squamous cell carcinoma (HNSC), kidney renal papillary cell carcinoma (KIRC), kidney renal papillary carcinoma (KIRP), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), stomach adenocarcinoma (STAD) and uterine corpus endometrial carcinoma (UCEC) than normal tissues. The gene discussed is XRCC4; the disease is colon adenocarcinoma.