For example, XRCC4 expression had a strong association with STAT1 in Th1 cells, CD86 in monocyte, NRP1 in DC, IL10 in TAM, MS4A4A in M2 macrophage, STAT5B in Tregs, STAT6 in Th2 in most of cancer types, detailed information was shown in Additional file 6: Table s3. This evidence concerns the gene MS4A4A and cancer.