It is known that COVID-19 adheres to ACE 2 receptors on endothelial cells and brain microglia could induce transformations in the renin-angiotensin-aldosterone system (RAAS) in favor of the classical pathway, thus leading to changes in vasoconstriction and in blood pressure, indirectly impacting on the cerebrovascular system leading to PRES. Here, REN is linked to Posterior Leukoencephalopathy Syndrome.