For a PDAC surgical resection case PR02, based on both MSK-IMPACT sequencing (high-depth targeted sequencing) and bulk WES, we identified that the major tumor clone carried the hotspot KRAS p.G12D mutation; hints of a minor KRAS p.G12V clone existed but were on the borderline of the technologies’ detection sensitivity (Fig. 4a). This evidence concerns the gene KRAS and neoplasm.