Nonetheless, both driver gene variants (KRAS p.G12V, SMAD4 p.A39T) identified by bulk WES of this same sample were identified with high-quality read data (Supplementary Fig. 6a, b) and indicated 113 likely tumor cells (23.6% of all) captured for this sample based on the presence of the clonal KRAS variant (Fig. 3b, c). The gene discussed is SMAD4; the disease is neoplasm.