In contrast to aFib-RS, high Fib-TBRS expression failed to segregate relapsing patients in the CMS4 CRC subtype (Supplementary Table 2c), yet elevated expression of Fib-TBRS and FAP (+) or (−) Fib-TBRS subsets were associated with an increased risk of relapse in the overall CRC population (Supplementary Table 2c). Here, DNMT3A is linked to colorectal carcinoma.