TGFB1 and colorectal carcinoma: The levels of both TGFB1 and the gene expression program activated by TGF-beta 1 in colon fibroblasts (Fib-TBRS; see “Methods”) were robustly correlated with aFib-RS in patients’ tumors (Fig. 3g), therefore indicating that these processes are concurrently modulated in CRC.